SBIR & Small Business Grants
Small Business Innovation Research (SBIR) and STTR grants from NIH, NSF, DOD, DOE, and NASA. Phase I feasibility awards up to $300K, Phase II development up to $2M.
Connect small businesses and startups with America's Seed Fund — federal R&D grants with no equity dilution.
Active Opportunities (47)
This notice of funding opportunity (NOFO), utilizing the U24 grant funding mechanism, encourages applications for a coll...
The Office of Disease Prevention (ODP) and participating National Institutes of Health (NIH) Institutes, Centers, and Of...
The purpose of this Notice of Funding Opportunity (NOFO) is to leverage NICHD clinical research Network infrastructure r...
The purpose of this announcement is to encourage investigators to pursue translational activities and clinical feasibili...
The Blueprint Neurotherapeutics Network for Biologics (BPN-Biologics) provides support for biologic-based therapeutic di...
The purpose of this Funding Opportunity Announcement (FOA) is to support collaborative research projects designed to add...
The purpose of the NHLBI Career Transition Award (K22) program is to provide highly qualified postdoctoral fellows in th...
This Notice of Funding Opportunity (NOFO) encourages cooperative agreement applications for investigator-initiated, mult...
This Notice of Funding Opportunity (NOFO), utilizing the U24 grant funding mechanism, encourages applications for a coll...
This notice of funding opportunity (NOFO) encourages applications for investigator-initiated multi site clinical trials ...
NIMH seeks applications for research projects to evaluate the effectiveness of therapeutic and service delivery interven...
The Blueprint Neurotherapeutics Network (BPN) invites applications from neuroscience investigators seeking support to ad...
The objective of this funding opportunity is to support investigator-initiated, phase I clinical trials for diagnostic a...
The objective of this funding opportunity is to support investigator-initiated, Phase I clinical trials for diagnostic a...
The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to acceler...
The goal of this Notice of Funding Opportunity (NOFO) is to provide funding support for the pre-clinical and early stage...
This Notice of Funding Opportunity Announcement (NOFO) intends to supports studies that are both necessary and sufficien...
The Disability and Rehabilitation Engineering program is part of the Engineering Biology and Health cluster, which also ...
U.S. Embassy Praia welcomes the submission of project applications for funding through the Ambassadorâs Special Self-H...
**UPDATE 5 APRIL 2024: The proposal submission date has been updated to 24 April 2024. The FOA has been amended to refle...
The purpose of this Broad Agency Announcement (BAA) under Federal Acquisition Regulation (FAR) Part 35 and Funding Oppor...
NIMH seeks applications for pilot effectiveness projects to evaluate the preliminary effectiveness of therapeutic and se...
The purpose of this Notice of Funding Opportunity (NOFO) is to encourage cooperative agreement applications to support e...
Convergence research is a means for solving vexing research problems, in particular, complex problems focusing on societ...
CREST Center awards provide support to enhance the research capabilities of Minority-serving institutions (MSIs) through...
Request for Applications Description: The U.S. Integrated Ocean Observing System (IOOS®) is a national and regional par...
The Collaboratory to Advance Mathematics Education and Learning (CAMEL) for K-12 initiative aims to advance mathematics ...
The National Aeronautics and Space Administration (NASA) Headquarters, Space Technology Mission Directorate (STMD) will ...
The U.S. National Science Foundation (NSF) continues to develop and nurture a national innovation ecosystem that guides ...
The Office of Nuclear Energyâs (NE) mission is to advance nuclear energy science and technology to meet U.S. energy, e...
The U.S. NSF Directorate for Technology, Innovation and Partnerships (NSF TIP) partners across sectors to advance three ...
Provides loans and grants to Microenterprise Development Organizations (MDOs) to provide microloans for microenterprise ...
The Sociology Program supports basic research on all forms of human social organization - societies, institutions, group...
Amendment 0006 The purpose of this amendment is to extend the due date for acceptance of White Papers. All other terms a...
The U.S. Military Academy at West Point's mission is "to educate, train, and inspire the Corps of Cadets so that each gr...
AEIF is designed to increase the impact of the U.S. governmentâs investment in exchange participants and programs by h...
Summary: The fiscal year 2026 (FY26) Peer Reviewed Cancer Research Program (PRCRP) Clinical Trial Award (CTA) supports t...
The U.S. Department of Stateâs Embassy Managua announces an open competition for the Public Diplomacy Small Grants Pro...
NSF GRANTED supports innovative models of research enterprise administrative development and workforce training infrastr...
U.S. Embassy Buenos Aires announces an open competition to promote innovation, cybersecurity, and responsible Artificial...
This Notice of Funding Opportunity (NOFO) solicits cooperative agreement research applications to support a multidiscipl...
This Notice of Funding Opportunity (NOFO) encourages collaborations between the life and physical sciences that: 1) appl...
The purpose of this Funding Opportunity Announcement is to invite proposals for funding from established organizations i...
The U.S. Department of State's Mission Poland announces an open competition for programs inspired by America's 250th ann...
The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Manage...
Modification 0002 Annoucement (04/21/26): Extended LOI due date to 4/24/2026 Extended TA1 due date to 5/29/2026 Extended...
The Engineering Biological and Biomedical Systems (EBBS) program expands our understanding of biological and physiologic...
The SBIR (Small Business Innovation Research) and STTR (Small Business Technology Transfer) programs collectively represent the largest source of early-stage, non-dilutive R&D funding for U.S. small businesses, with over $4 billion awarded annually across eleven participating federal agencies. SBIR Phase I awards — typically $150,000 to $300,000 for 6 months — fund proof-of-concept research. Phase II awards of up to $2 million fund full prototype development, with some agencies like NIH offering Phase II awards up to $3.5 million. STTR requires formal partnering with a U.S. research institution for at least 30% of the work. The SBA's America's Seed Fund portal (seedfund.sba.gov) lists all open solicitations by agency and technology topic. Critically, SBIR grants require no equity dilution and companies retain full intellectual property rights — making them strategically superior to early venture funding for companies with strong technology focus. DOD alone funds over $1 billion in SBIR awards annually across its service branches, covering dual-use technologies in AI, materials science, communications, and autonomy.
Frequently Asked Questions
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